VolumeVol. 58 • Number No. 4 • October-December 2020 Back

Consensus Statement

Philippine Consensus Statement on the Use of Ketogenic Diet and Intermittent Fasting Diet on Adults for Weight Reduction

Authors: Elmer Jasper B. Llanes, Eddieson M. Gonzales, Don Robspierre Reyes, Maria Julia G. Gubat, Ma. Eloisa Estipona-Villaraza, Princess Jereme T. Bautista, Lourdes Ella G. Santos, Nanette Rey, Olive Q. De Guzman-Quizon, Jim Saret, Toni Saret, Nemencio A. Nicodemus Jr., Bien J. Matawaran, Cecilia A. Jimeno

DOI: 10.65564/pjim.3d944b84ce

Date of Publication: December 2020


Abstract

Globally, overweight and obesity prevalence have been steadily rising over the years and reaching epidemic proportions due to urbanization,globalization,changes in dietary habits and a decrease in physical activity brought about byeasy access to basic needs. Ketongenic Diet (KD) and Intermittent Fasting (IF) diets are common topics in public fora and much confusion centers on different versions offered, raising concerns for safety. The aim of this group is to release a community based expression of consensus statements regarding KD and IF based on available clinical trial evidence.


References

  1. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
  2. http://www.fnri.dost.gov.ph/images/sources/anthrop_adults-revised.pdf
  3. Geronimo FR, Punzalan FE, Abarquez RF Jr.,Cabral EI. Clustering of risk factors,metabolic syndrome,and risk for coronary heart disease for hypertension.Philippine Journal of Cardiology 2006;34(2):62-70.
  4. Ho H,Gatbonton P, atongbacal MA, Lim Abrahan MA. The lipid prole of diabetic patients at the Diabetes Clinic of the Philippine General Hospital. Philippine Journal of Internal Medicine 2000;38:16-20.
  5. Azevedo, Ikeoka,Caramelli.Effects of Intermittent Fasting in Metabolism in Men.Rev Assoc Med Bras.2013;59(2):167-173.
  6. Antoni R, Johnsons KL, Collins AL and Roberts on D. Intermittent v. continuous energy restriction:differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants. British Journal of Nutrition(2018),119,507–516.
  7. Patterson RE and Sears DD. Metabolic Effects of Intermittent Fasting. Annual Review of Nutrition. 2017, 37:1-23.
  8. Stockman MC, Thomas D, Burke J, Apovian CM. Intermittent Fasting: Is the Wait Worth the Weight. Curr Obes Rep. 2018 Jun;7(2):172-185. doi: 10.1007/s13679-018-0308-9.
  9. GolbidiS.,DaiberA.etal.Health Benefits of Fasting and Caloric Restriction.Curr Diab Rep(2017)17:123.https://doi.org/10.1007/s11892-017-0951-7.
  10. HarrisL,HamiltonS,AzevedoL,et.al.Intermittent fasting interventions for treatment of over weight and obesity in adults: asystematic review and meta-analysis.JBI Database System RevImplement Rev2018;16(2):507-547.
  11. BarnoskyA,Hoddy K, UntermanT, Varady K. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention:are view of human findings.Translational Research2014;164:302–311
  12. Lee MJ, Wu Y, Fried SK. Adipose tissue heterogeneity : implication of depot differences in a dipose tissue for obesity complications. Mol Aspects Med 2013;34:1–11.
  13. Amason TG , Bowen MW, Mansell KD. Effects of intermittent fasting on health markers in those with type 2 diabetes: A pilot study.World J Diabetes 2017April15;8(4):154-164.
  14. S.Carter,P.M.Clifton,J.B.Keogh,The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial, Diabetes Research and Clinical Practice(2016),doi:http://dx.doi.org/10.1016/j.diabres.2016.10.010
  15. Corley BT, Carroll RW, Hall RM, et.al. Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized control led  trial.Diabet.Med.2018;35:588–594.
  16. Paoli A., Rubini A et al. Beyond  weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European Journal of Clinical Nutrition (2013) 67, 789–796; doi:10.1038/ejcn.2013.116
  17. Sumithran P., Prendergast LA et al. Ketosis and appetite-mediating nutrients and hormones after weight loss. European Journal of Clinical Nutrition (2013) 67, 759–764; doi:10.1038/ejcn.2013.90
  18. Bueno NB,Vieira del Melo  IS,et. al. Very-low-carbohydrate keto genic diet v.low-fat diet for long-term weight loss:a meta-analysis of randomised controlled trials.Br J Nutr 2013;110:1178-1187.
  19. Hall KD, Chen KY, Guo J, et. al. Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men. Am J Clin Nutr 2016;104:324–33.
  20. HM Dashti, TC Mathew,T Hussein,et al.Long-term effects of a ketogenic diet in obese patients.Exp C lin Cardiol 2004;9(3):200-205.
  21. Saslow LR, Mason AE, Kim S, et. al An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Life style Recommendations Versus a Plate Method Diet in Overweight Individuals with Type 2 Diabetes: AR a randomized Controlled Trial. J Med Internet Res.2017 Feb13;19(2):e36.doi:10.2196/jmir.5806.
  22. Saslow LR, Daubenmier JJ, Moskowitz JT, et al.Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus verylow-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes. Nutr Diabetes. 2017 Dec 21; 7(12):304.doi:10.1038/s41387-017-0006-9.
  23. Goday A, Bellido D, SajouxI,et al.Short-term safety, tolerability and efficacy of a verylow-calorie-keto genic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus.Nutr Diabetes.2016 Sep 19; 6(9):e230.doi:10.1038/nutd.2016.36.
  24. Hussain TA, Mathew TC, Dashti AA, et al. Effect of low-calorie versus low-carbohydrate keto genic diet in type 2 diabetes. Nutrition.2012Oct;28(10):1016-21.
  25. Bhanpuri NH, Hallberg SJ, Williams PT, et al. Cardiovascular disease risk factor responses to a type 2 diabetes care model including nutritional ketosis induced by sustained carbohydrate restriction at 1year: an open label,non-randomized, controlled study. Cardiovasc Diabetol (2018)17:56
  26. Hallberg SJ, McKenzie AL, Williams PT,et.al. Diabetes Ther 2018;9:583-612.
  27. Hayami, T.,et al.,Case of ketoacidosis by a sodium-glucose cotransporter 2 inhibitor in a diabetic patient with a low-carbohydrate diet. Journal of Diabetes Investigation, 2015.6:p.587-590.
  28. Westman EC, Tondt J, Maguire E, Yancy WS. (2018): Implementing a low carbohydrate, ketogenic diet to manage type 2 diabetes mellitus, Expert Review of Endocrinology & Metabolism, DOI:10.1080/17446651.2018.1523713