PJIM has embarked upon a significant new phase in its distinguished history. The transition to a modern digital publishing platform represents far more than a technological upgrade in manuscript submission, review, and publication processes. It reflects the Philippine College of Physicians’ continuing commitment to innovation, excellence, and responsiveness to the evolving needs of the medical and scientific community, while remaining steadfast in the values that have guided the Journal for more than sixty years.

The Philippine Journal of Internal Medicine (PJIM) enters a new chapter with its transition to a digital platform, building upon more than six decades of service to the Philippine internal medicine community. While scientific rigor, integrity, meaningful peer review, and relevance to clinical practice will continue to guide the journal, digital publishing offers new opportunities for researchers, reviewers, and readers to engage more actively with PJIM and contribute to its continuing legacy.

Urinary stone disease remains a significant global and national health concern. This underscores the need for measures to improve disease outcomes. The development and implementation of clinical practice guidelines for urolithiasis was deemed essential due to variations in practice and the evolving urologic field with its emerging interventions, which may have significant cost implications.

Detecting frailty in older people with diabetes mellitus is important to target interventions that reduce functional decline and risk of disability. This study aims to determine the prevalence and associated factors of frailty among geriatric patients with Type 2 diabetes mellitus (T2DM).

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target inhibitory receptors expressed on T cells and are associated with a variety of immune-related adverse events (irAE) including the kidneys. This study attempted to determine the factors, incidence, electrolyte and urine abnormalities, clinical outcomes, and development of chronic kidney disease (CKD) among patients who developed immune checkpoint inhibitor-associated acute kidney injury (ICI AKI).

Hepatocellular carcinoma (HCC) is a frequent and major cause of cancer mortality in the Philippines, mostly due to its late diagnosis. For better survival, early detection is essential. This study compared the performance of three surveillance strategies in the detection of HCC: a Modified GALAD score (a serum biomarker-based model), ASAPUSTE score (blood plus ultrasound and transient elastography), and the standard surveillance strategy, serum AFP plus ultrasound.

Retroperitoneal liposarcoma is an extremely rare type of malignancy that originates from fat cells of the body and is found in the retroperitoneum. Early diagnosis is challenging due to the lack of distinct clinical symptoms. This is a case of a 35-year-old Filipino Female who presented with an intra-abdominal mass associated with abdominal discomfort, bloated sensation, and rapidly increasing abdominal girth for the last 2 months.

Primary appendiceal tumors are rare, as they account for only 0.5 to 1% of all appendiceal biopsy specimens. The mucinous type of adenocarcinoma has an incidence of only 10%. This type can have different manifestations, of which an exceptionally small fraction manifests as an ovarian tumor. Thus, we report a rare case of primary appendiceal mucinous adenocarcinoma in a 49-year-old woman, presenting clinically with an ovarian mass.

The adrenal gland is an uncommon site for infection such as extrapulmonary tuberculosis (TB). In most cases, TB of the adrenals involve both glands however it may also occur rarely as unilateral. At present there are only few data reported with unilateral adrenal TB. We report a case of unilateral adrenal tuberculosis seen in a 39-year-old female who presented with weight loss, abdominal pain, diarrhea, and bloatedness.

Langerhans cell histiocytosis (LCH) is a rare neoplastic proliferation of dysfunctional antigen presenting cells. Granulomatous in character, LCH may affect any organ system and any age group. Several cases worldwide are mostly studied among the pediatric population with only finite cases among adults. This is a case of a 25-year old Filipino female who presented with granulomatous anterior chest lesions.

Eruptive Xanthomas are rare manifestations of severe hypertriglyceridemia presenting as multiple erythematous to yellowish dome-shaped papules, commonly involving the extensor surfaces and buttocks. Prompt multidisciplinary recognition is vital given the associated risks of atherosclerosis and pancreatitis. A 46-year-old Filipino male presented with a 7-month history of asymptomatic whitish to yellowish dome-shaped papules on the nape, trunk, lower back and extremities.